DNA and synthetic biology technologies edit, assemble, store, or organize genetic material. They support research and applications in medicine, manufacturing, and data storage, while raising questions about accuracy, safety, and governance.
Base editing is a genome-editing approach that chemically changes one DNA or RNA base into another without making a double-strand break.
This topic covers methods for assessing unintended CRISPR-Cas genome edits and prime editing, a genome-editing approach that uses a prime editor and guide RNA to make targeted DNA changes.
DNA digital data storage encodes digital information in DNA molecules for long-term storage and later retrieval.
DNA origami and structural nanotechnology use DNA strands to assemble designed nanoscale structures and devices.
Enzymatic DNA synthesis uses enzymes to assemble DNA strands from nucleotide building blocks.
Epigenome editing is the targeted alteration of gene-regulating epigenetic marks or chromatin states without changing the underlying DNA sequence.
Gene drive systems are genetic mechanisms that bias inheritance so a genetic element spreads through a population faster than normal inheritance would allow.
Minimal synthetic genomes are engineered or synthesized genomes reduced to the genes considered necessary for a cell to function.
Multiplex genome editing is the simultaneous editing of multiple genetic targets in one organism or cell.
A synthetic biology chassis is a cell or organism used as an engineered host platform for building and operating biological systems.
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